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新浦京8883平台
师资力量

赵小虎     副教授

研究方向:有机化学;化学生物学

联系方式:          Email:xhzhao@scu.edu.cn

个人主页:点击进入

简历:

教育及工作经历:

2019.9 - 至今 新浦京8883平台  特聘副研究员

2017.8 - 2019.8 新加坡南洋理工大学,博士后(合作导师:Steve Zhou教授)

2016.7 - 2016.11 陕西科技大学,讲师

2011.9 - 2016.6 新浦京8883平台有机化学专业,博士(导师:冯小明教授)

2007.9 - 2011.6 新浦京8883平台化学专业,学士(导师:冯小明教授)

主要研究方向

1. 光诱导绿色合成方法学

2. 新型、高效、高选择性以及生物兼容性的生物偶联反应等交叉学科的研究,重点开展基于光诱导新型“点击”化学反应的设计和开发

主要工作业绩

主要围绕手性金属配合物催化不对称反应的研究,以及新型催化剂的设计和合成,并通过深入了解手性催化剂的设计规律,探索其反应活性和选择性,从而实现一系列结构复杂的手性分子以及药物的高效、高选择性的合成。在研究中,创新性地开发了一种廉价金属镍盐催化的不对称还原胺化反应,使用了安全且经济的甲酸/三乙胺作为氢源,高效实现了一系列化合物的还原胺化反应,并且完成了一步催化不对称降血糖药物hGK-hGKRP (Type II diabetes)的合成。这一方法为构建手性药物分子提供了一条简洁高效的路径,展现了重要的实用价值。

此外,也从事利用分子生物学探针在活体生物分子的光点击生物正交反应研究,主要开展新型高效、高选择性的光化学反应的开发。该类光化学反应可以通过严格的光激发在特定时间和地点研究特定细胞之间的相互作用,实现活体亚细胞精度的时空可控的生物正交标记。而且还可在高度拥挤的活体细胞内实现选择性的生物偶联。截止目前,总共发表SCI论文20余篇,其中以通讯作者和第一作者在Angew. Chem. Int. EdChem. CommunChem. Eur. J., 以及Org. Chem. Front.等杂志上发表高水平论文11篇,并有1篇作为亮点进行相关报道,其中刊登在Chem. Commun.上一篇文章被邀请作为front cover封面文章。

主要科研项目:

1. 四川省引进海内外高层次人才计划青年人才项目(即天府峨眉计划),(2021.1-2023.12),主持

2. 国家自然科学基金青年基金项目(2021.1-2023.12),批准号:22001181,主持

3. 四川省科技厅应用基础研究项目(2021.4-2023.3),批准号:2021YJ0407,主持

4. 四川大学引进人才科研启动经费项目(2019-2022)

主要奖励和荣誉

2021年四川省天府峨眉计划特聘专家

2015年四川大学国家奖学金                                    

2015年四川大学博士一等奖学金             

2015年四川大学“Moresco”奖学奖                                     

2013-2014学年四川大学优秀博士                           

2009-2010学年国家励志奖学金                             

2009-2010学年四川大学单项二等奖学奖      

2008-2009学年四川大学单项二等奖学奖      

2007-2008学年四川大学单项二等奖学奖

代表性成果 (获奖成果、专著、论文、专利)

通讯作者和第一作者论文:

1. Yuanqin Zheng, Yuqiao Zhou, Shichao Jiang, Xinyu Xie, Guangxi Du, Xin Shen, Xiaohu Zhao* and Zhipeng Yu *, Rapid construction of bicyclic triazoline skeletons with dual-state emission via cycloaddition reaction of 4-phenyl-1,2,4-triazoline-3,5-dione with vinyl azides, Org. Chem. Front., 2023, 10, 14951504.

2. Guangxi Du, Jielin Fu, Yuanqin Zheng, Fuqiang Hu, Xin Shen, Baolin Li, Xiaohu Zhao* and Zhipeng Yu, A facile and light-controllable drug combination for enhanced photopharmacology, Org. Biomol. Chem., 2023, 21, 10211026.

3. Xiaohu Zhao*, Yuqiao Zhou, Bao-Lin Li, Guangxi Du and Zhipeng Yu*, "Highly  diastereoselective cascade dearomatization of 3-(2-isocyanoethyl)indoles with nitrile imines: a facile access to unexpected polycyclic indolines", Org. Chem. Front., 2022, 9, 1336-1342.

4. Jianrong Steve Zhou,* Siyu Guo, Xiaohu Zhao and Yonggui Robin Chi, "Nickel-catalyzed enantioselective umpolung hydrogenation for stereoselective synthesis of β-amido esters", Chem. Commun., 2021, 57, 11501-11504.

5. Hui Liu, Tingting Zheng, Yuanqin Zheng, Baolin Li, Xinyu Xie, Xin Shen, Xiaohu Zhao* and Zhipeng Yu*, "Visible-light induced photo-click and release strategy between monoarylsydnone and phenoxylfumarate", Chem. Commun., 2021, 57, 8135-8138. (As Front Cover)

6. Xueting Wu, Jiajie Deng, Guiling Guo, Yuanqin Zheng, Qin Xiong, Tingting Zheng, Xiaohu Zhao,* and Zhipeng Yu*, "Spatiotemporal Resolved Live Cell Membrane Tracking through Photo-click Reactions Enriched in Lipid Phases" Chem. Eur. J. 2021, 27, 11957-11967.

7. Xiaohu Zhao, Haiyan Xu, Xiaolei Huang and Jianrong Steve Zhou*, "Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates and a Phosphinamide via Nickel Catalysis" Angew. Chem. Int. Ed. 2019, 58, 292-296. Highlight by Synfacts 2019, 15(03), 0258.

8. Xiaohu Zhao, Hongjiang Mei, Qian Xiong, Kai Fu, Lili Lin*, Xiaohua Liu and Xiaoming Feng*, "Highly enantioselective construction of carbazole derivatives via [4+2] cycloaddition of silyloxyvinylindoles and β,γ-unsaturated α-ketoesters " Chem. Commun. 2016, 52, 10692-10695.

9. Xiaohu Zhao, Xiaohua Liu*, Hongjiang Mei, Jing Guo, Lili Lin. Xiaoming Feng*, "Asymmetric Dearomatization of Indoles through Michael/FriedelCrafts-Type Cascade to Construct Polycyclic Spiroindolines", Angew. Chem. Int. Ed. 2015, 54, 4032-4035.

10. Xiaohu Zhao, Xiaohua Liu, Qian Xiong, Hongjiang Mei, Baiwei Ma, Lili Lin and Xiaoming Feng*, "The asymmetric synthesis of polycyclic 3-spirooxindolealkaloids via the cascade reaction of 2-isocyanoethylindoles" Chem. Commun. 2015, 51, 1607616079.

11. Xiaohu Zhao, Mingsheng Xie, Xiaohua Liu, Yulong Zhang, Xiao Xiao, Lili Lin, and Xiaoming Feng*, "Chiral N,N′-Dioxide–Yttrium Triflate Complexes-Catalyzed Asymmetric Aldol Cyclization of α-Keto Esters with α- Isothiocyanato Imide", Adv. Synth. Catal, 2013, 355, 3253–3262.

代表性合作作者论文:

12. Lijun Deng, Cefei Zhang, Baolin Li, Jielin Fu, Zhong Zhang, Sitong Li, Xiaohu Zhao, Zhishan Su, Changwei Hu* and Zhipeng Yu*, Photo-induced defluorination acyl fluoride exchange as a fluorogenic photo-click reaction for photo-affinity labeling, Chem. Sci., 2023, 14, 36303641.

13. Xinyu Xie, Fuqiang Hu, Yuqiao Zhou, Zhihao Liu, Xin Shen, Jielin Fu, Xiaohu Zhao, Zhipeng Yu*, Photoswitchable Oxidopyrylium Ylide for Photoclick Reaction with High Spatiotemporal Precision: A Dynamic Switching Strategyto Compensate for Molecular Diffusion, Angew. Chem. Int. Ed. 2023, 62, e2023000.

14. Tingting Zheng, Jielin Fu, Qin Xiong, Xin Shen, Baolin Li, Xiaohu Zhao and Zhipeng Yu*, Photo-regulated genetic encodingof dibenzo[c,g][1,2]diazocine on proteins via configuration switching, Chem. Commun., 2023, 59, 1201-1204.

15. Xin Shen, Cefei Zhang, Fengying Lan, Zhishan Su, Yuanqin Zheng, Tingting Zheng, Qin Xiong, Xinyu Xie, Guangxi Du, Xiaohu Zhao, Changwei Hu,* Pengchi Deng,* and Zhipeng Yu* Dibenzo[b,f][1,4,5]chalcogenadiazepine Photoswitches: Conversion of Excitation Energy into Ring StrainAngew. Chem.Int. Ed., 2022, 61, e2022094.

16. Qin Xiong, Tingting Zheng, Xin Shen, Baolin Li, Jielin Fu, Xiaohu Zhao, Chunxia Wang and Zhipeng Yu* Expanding the functionality of proteins with genetically encoded dibenzo[b,f][1,4,5]thiadiazepine: a photo-transducer for photo-click decoration, Chem. Sci., 2022, 13, 35713581.

 

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