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新浦京8883平台
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付绍敏     副教授

研究方向:有机化学

联系方式:          Email:fsm09@aliyun.com

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简历

主要教育和工作经历

2024.1- 新浦京8883平台,副教授

2018.5-2023.12 新浦京8883平台,特聘副研究员

2015.6-2017.12   清华大学化学系,博士后;合作导师:刘强教授

2009.9-2015.4 华南理工大学,化学与化工学院,有机化学专业,博士(指导老师:曾伟教授)

2005.9-2009.7 华南农业大学,理学院,应用化学毕业,学士(指导老师:倪春林教授)

主要研究方向

研究兴趣:

1.基于天然产物全合成的串联环化反应研究

2.天然产物全合成

科研项目:

1. 国家自然科学基金面上项目(2024.1-2027.12),项目批准号:22371192,主持

2. 四川省科技厅,面上项目(2023.1-2024.12),项目批准号:2023NSFSC0105主持

3. 四川大学01”创新项目,2021, 主持

4. 四川大学双百B人才项目, 2021,主持

5. 国家自然科学基金青年基金项目(2020.1-2022.12), 项目批准号:21901170, 主持

6. 国家自然基金委-区域创新联合发展基金,项目批准号:U19A2014,参与

7. 四川大学引进人才科研启动经费项目(2019-2021)

8. 中国博士后科学基金,二等(2015-2017)

获得奖励:

1. 四川大学2021年度本科课堂教学质量优秀奖, 2022

2. 四川大学2022届本科优秀毕业论文二等奖,指导教师,2022

3. 四川省特聘专家, 2021

4. 博士后创新研究基金, 华南理工大学, 2012

5. 华南理工大学学术论文奖, 2011 2015

6. 华南理工大学研究生新生一等奖学金,2009

7. 华南农业大学学生二等奖学金, 2009

8. 华南农业大学优秀毕业论文,2009

代表性成果 (获奖成果、专著、论文、专利)

研究兴趣主要围绕含季碳中心的多环骨架结构为研究对象,针对性开发高效合成策略,拓展其在复杂分子合成中的应用(1)。针对含季碳中心的不同桥环骨架,创新性地发展了光催化烯醇硅醚的串联反应以及铁催化还原aldol反应。针对含季碳中心的不同并环骨架,发展了钯催化半片呐醇重排串联Csp2-H芳基化反应,二醇氧化断裂串联aldol反应以及铁促进[5+2]环加成反应。并以此实现了C20氧化对映贝壳杉烷二萜sculponin U和丁香烷倍半萜rumphellclovane E的全合成以及数个天然产物核心骨架的构建。建立了光催化烯醇硅醚的串联反应合成桥环和稠环骨架的方法学。开发了反常区域选择性的铁催化γ/δ-烯基烯酮串联环化反应合成双环环丙醇的策略。累计发表论文 46篇,它引超过 1200 ,其中以第一(共同)或者共同通讯作者发表论文31篇,包括 J. Am. Chem. Soc. 发表 2 篇,Angew. Chem. Int. Ed. 发表 2 Org. Lett. 7Chem. Comm. 1OCF 3JOC 2两篇论文入选ESI高被引论文,2篇论文引用超过200次,最高它引超过250

1含季碳中心的多环骨架结构及相应合成策略

Selected papers:

23. Wei Cao, Zhen Wang, Yan Hao, Tianli Wang, Shaomin Fu* and Bo Liu*. Total Synthesis of Sculponin U, A C-20 Oxygenated ent-Kaurane Diterpenoid, through Photoinduced Radical Cascade Cyclization. Angew. Chem. Int. Ed., 2023, 52, e202305516.

22. Jiaxin Du, Shaomin Fu* and Bo Liu*. A Photo-induced Radical Cascade Cyclization for the Synthesis of Angularly Fused Tricyclic Compounds. Org. Lett., 2024, accepted.

21. Shaomin Fu, and Bo Liu*. Total Synthesis with Gram-scale Radical Process: An Inspiration for Pharmaceutical Industry. Org. Process. Res. Dev., 2024, 28, 847859.

20. Ying Sun, Jing Feng, Song Qin, Shaomin Fu* and Bo Liu*. Asymmetric Construction of the Core of C6, C7-Epoxy Daphnane Diterpenoid Orthoesters. Org. Lett., 2023, 25, 80728076.

19. Ganxing Huang, Zhengsong Huang, and Xianjian Ma, Zhihu Feng, Fengxia Yuan, Song Qin, Shaomin Fu* & Bo Liu *. Asymmetric Total  Syntheses of Sarbracholide and Shizukaol B. Org. Chem. Front., 2023., 10, 3591-3597. 

18. Lizhi Xun, Zhijiang Zhang, Yuqiao Zhou, Song Qin*, Shaomin Fu*, and Bo Liu. Stereo-divergent Construction of [5, 5]-Oxaspirolactone of Phainanoids. J. Org. Chem., 2023, 88, 3987-3991.

17. Mengqin Hu, Wei Cao, Zhen Wang, Yan Hao, Ganxing Huang, Yuqiao Zhou, Song Qin, Shaomin Fu,* and Bo Liu*. Construction of Angularly Fused Tricyclic Compounds via Photo-induced Radical Cascade Cyclization. Chin. J. Chem., 2023, 41, 25022506.

16. Cichang Ling, Zhengsong Huang, Yuqiao Zhou, Shaomin Fu*, and Bo Liu*. Alternative Construction of the Core of Lindenane Sesquiterpenoid. Chin. J. Chem., 2023, 41, 1931-1936.

15. Guoshen, Shaomin Fu*., Bo Liu*. Oxime Ester-Enabled Anti-Markovnikov Hydrosilylation of Alkenes. Chem. Commun., 2022, 58(87), 12204-12207.

14. Rong Liu, Mengwei Xia, Cichang Ling, Shaomin Fu*, Bo Liu*. Construction of the Tetracyclic Core Structure of Dysiherbols A−C. Org. Lett., 2022, 24(8), 1642-1646. Highlighted by CBG 资讯.

13. Ying Xie, Wei Huang, Song Qin, Shaomin Fu* and Bo Liu *, Catalytic Radical Cascade Cyclization of Alkene-Tethered Enones to Fused Bicyclic Cyclopropanols. Org. Chem. Front., 20218, 6678-6686.

12. Yi Man, Chengying Zhou, Shaomin Fu*, Bo Liu*. Synthetic Study Aiming at Tricyclic Core of 12-epi-JBIR-23/24. Org. Lett., 2021, 23, 3151-3156.

11. Guanggen Liu+, Zhijiang Zhang+, Shaomin Fu*, Bo Liu*. Asymmetric Total Synthesis of Rumphellclovane E. Org. Lett., 2021, 23, 209-295. + These authors contribute equally to this article. Top ten downloaded article in Organic Letters in December 2020. Highlighted by synfacts, Synfacts 2021, 17(03), 248.

10. Shaomin Fu, Bo Liu.* Recent Progress on Synthesis of Limonoids and Limonoid-like Natural Products. Org. Chem. Front., 2020, 7(14), 1903-1947 (review)

9. Bo Liu*,  Shaomin Fu, Chengying Zhou. Nat. Prod. Rep., 2020, 37, 1627 - 1660. (review)

8. Guili Zhu, Chengying Zhou, Song Chen, Shaomin Fu*, Bo Liu*. Construction of BCDEF Core of Andilesin C. Org. Lett., 2019, 19, 7809.

7. Jing Feng, Hongli Yin, Yi Man, Shaomin Fu* and Bo Liu*. Chin. J. Chem. 2018, 36, 831-836. Selected as back cover paper.

Prior to Sichuan University

6. Shaomin Fu, Zhihui Shao, Yujie Wang, Qiang Liu*. J. Am. Chem. Soc., 2017, 139, 11941-11948. († Co-first Author.). Hightlighted by X-MOL. Highly Cited Paper (226 times).

5. Shaomin Fu, Nan-Yu Chen, Xufang Liu, Zhihui Shao, Shu-Ping Luo, and Qiang Liu*. J. Am. Chem. Soc., 2016, 138, 8588-8594. († Co-first Author.). Highly Cited Paper (206 times).

4. Zhihui Shao, † Shaomin Fu, † Mufeng Wei, Shaolin Zhou, Qiang Liu*. Angew. Chem. Int. Ed., 2016, 55, 14653- 14657. († Co-first Author.). Highlighted by Chin. J. Org. Chem. 2017, 37, 242-244. (134 times)

3. Shaomin Fu, Honghao Yang, Guoqiang Li, Yuanfu Deng, Huanfeng Jiang and Wei Zeng *. Org. Lett., 2015, 17(4), 1018- 1021.

2. Shaomin Fu, Huanfeng Jiang, Yuanfu Deng, and Wei Zeng *. Adv. Synth. Catal. 2011, 353, 2795- 2804.

1. Libo Liang, Shaomin Fu, Dongen Lin, Xiao-Qi Zhang, Yuanfu Deng, Huanfeng Jiang and Wei Zeng*. J. Org. Chem., 2014, 79, 9472- 9480. († Co-first author.)

 

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