>简 历教育及工作经历2006.9~2010.6 新浦京8883平台化学专业,学士 2010.9~2015.6 四川大学化学学..." />

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新浦京8883平台
师资力量

曹伟地     教授,博导

研究方向:不对称合成,光催化,有机硅化学,手性药物和生物活性化合物合成

联系方式:          Email:wdcao@scu.edu.cn

个人主页:点击进入

简历:

2006.9-2010.6 新浦京8883平台化学专业,学士

2010.9-2015.6 新浦京8883平台有机化学专业,博士(导师:冯小明教授)

2015.9-2018.2 新加坡南洋理工大学,博士后(导师: Choon-Hong Tan教授)

2018.4-2021.8 新浦京8883平台  副教授

2021.9-至今   新浦京8883平台  教授

主要研究方向

不对称催化、光催化、自由基化学、有机硅化学、手性药物和生物活性化合物的合成

主要工作业绩

主要从事不对称催化和有机硅化学方面的研究,发展了系列不对称催化新方法和新策略,为一些具有生物活性手性化合物的合成提供了高效新途径。目前以第一作者或通讯作者在J. Am. Chem. Soc.Angew. Chem.CCS Chem.等化学期刊发表SCI论文30余篇,其中应邀撰写综述或亮点评述6篇,多篇论文被选为VIP论文或被SynfactsOrg. Chem. Highlights等杂志评述,授权中国发明专利2项。主持国家自然科学基金面上项目、青年科学基金项目、四川省科技厅应用基础研究项目,作为骨干成员参与国家自然科学基金重大研究计划集成项目、区域联合基金项目。2019年获教育部自然科学奖一等奖(第五完成人),2021年入选四川省高层次人才引进计划,授予四川省特聘专家称号;2021年入选四川大学青年科技领军人才培育计划和双百人才工程”B计划,获四川大学大学生创新创业与实践教育优秀指导教师称号。

代表性成果 (获奖成果、专著、论文、专利)

1. Lili Feng, Xiaofan Chen, Ning Guo, Yuqiao Zhou, Lili Lin, Weidi Cao,* Xiaoming Feng,* Visible-Light-Induced Chemo-, Diastereo- and Enantioselective α-C(sp3)−H Functionalization of Alkyl Silanes, Chem. Sci. 2023, 14, 4516−4522.

2. Xinpeng Sang, Yuhao Mo, Shiya Li, Xiaohua Liu, Weidi Cao,* Xiaoming Feng,* Bimetallic Tandem Catalysis-Enabled Enantioselective Cycloisomerization/Carbonyl–ene Reaction for Construction of 5-Oxazoylmethyl a-Silyl Alcohol, Chem. Sci. 2023, 14, 8315−8320.

3. Ning Guo, Yao Luo, Lili Feng, Zhili Liu, Weidi Cao,* Xiaoming Feng,* Radical Conjugate Addition of Acylsilane Enabled by Synergistic Photoredox and Lewis Acid Catalysis, Asian J. Org. Chem. 2023, 12, e202300164.

4. Qianchi Lin, Siyuan Wang, Rui Weng, Weidi Cao,* Xiaoming Feng,* Chiral Lewis Acid-Catalyzed Asymmetric Multicomponent Michael Reaction through [1,2]-Phospha-Brook Rearrangement, Org. Lett. 2023, 25, 6262−6266.

5. Wanlong Xiao, Fang Li, Xiaohua Liu, Weidi Cao,* Xiaoming Feng,* Catalytic Asymmetric Synthesis of Axially and Centrally Chiral 1,2-Dihydrobenzofuro[3,2-b]pyridines through a [2+2] Cycloaddition/Retroelectrocyclization/Re-Cycloaddition Cascade, Org. Lett. 2023, 25, 8005–8009.

6. Fengcai Zhang, Yuqiao Zhou, Hansen Zhao, Long Chen, Weidi Cao,* Xiaoming Feng,* Catalytic Asymmetric [3 + 2] Cycloaddition of Exocyclic Enol Ethers for the Synthesis of Spiroketals, Precis. Chem. 2023, 1, 423–428.

7. Liuzhen Hou, Xiaohua Liu, Weidi Cao,* Xiaoming Feng,* Recent Advances in Visible Light-induced Asymmetric Transformations of Carbonyl Compounds into Chiral Alcohols, ChemCatChem 2023, 15, e202300893.

8. Weidi Cao, Xiaohua Liu,* Recent Advances on Catalytic Enantioselective Protonation for Construction of α-Tertiary Carbonyl Compounds, Chin. J. Org. Chem. 2023, 43, 961973.

9. Liuzhen Hou, Yuqiao Zhou, Han Yu, Tangyu Zhan, Weidi Cao,* Xiaoming Feng,* Enantioselective Radical Addition to Ketones through Lewis Acid-Enabled Photoredox Catalysis, J. Am. Chem. Soc. 2022, 144, 22140−22149. (Most Read Articles, highlighted by Synfacts)

10. Guihua Pan, Changli He, Min Chen, Qian Xiong, Weidi Cao,* Xiaoming Feng,* Synthesis of Dihydroisoquinoline and Dihydropyridine Derivatives via Asymmetric Dearomative Three-component Reaction, CCS Chem. 2022, 4, 20002008.

11. Liangkun Yang, Wang-Yuren Li, Liuzhen Hou, Tangyu Zhan, Weidi Cao,* Xiaohua Liu, Xiaoming Feng,* Nickel-catalyzed Asymmetric Photoenolization/Mannich Reaction of (2-Alkylphenyl) Ketones, Chem. Sci. 2022, 13, 8576–8582.

12. Fengcai Zhang, Xinpeng Sang, Yuqiao Zhou, Weidi Cao,* Xiaoming Feng,* Enantioselective Synthesis of Azetidines through [3 + 1]-Cycloaddition of Donor−Acceptor Aziridines with Isocyanides, Org. Lett. 2022, 24, 1513−1517. (Highlighted by Org. Chem. Highlights)

13. Changqiang He, Zhikun Wu, Yuqiao Zhou, Weidi Cao,* Xiaoming Feng,* Asymmetric Catalytic Nitrooxylation and Azidation of β-Keto Amides/esters with Hypervalent Iodine Reagents, Org. Chem. Front. 2022, 9, 703−708.

14. Li Dai, Wen Liu, Yuqiao Zhou, Zi Zeng, Xinyue Hu, Weidi Cao,* Xiaoming Feng,* Catalytic Asymmetric Halogenation/Semipinacol Rearrangement of 3-Hydroxyl-3-vinyl Oxindoles: A Stereodivergent Kinetic Resolution Process, Angew. Chem. Int. Ed. 2021, 60, 2659926603.

15. Mingming Guan, Shiyu Wang, Yao Luo, Weidi Cao,* Xiaohua Liu, Xiaoming Feng,* Catalytic Asymmetric Addition of Thiols to Silyl Glyoxylates for Synthesis of Multi-hetero-atom Substituted Carbon Stereocenter, Chem. Sci. 2021, 12, 7498–7503.

16. Mingyi Jiang, Kaiqi Hu, Yuqiao Zhou, Qian Xiong, Weidi Cao,* Xiaoming Feng,* Enantioselective Isocyanide-based Multicomponent Reaction with Alkylidene Malonates and Phenols, Org. Lett. 2021, 23, 5261–5265.

17. Weidi Cao, Xiaohua Liu,* Asymmetric Formal Hetero-Ene Reaction of Allylgold Intermediates, Chin. J. Org. Chem. 2021, 41, 857−858.

18. Ziwei Zhong, Zhijie Xiao, Xiaohua Liu, Weidi Cao,* Xiaoming Feng,* Catalytic Asymmetric Synthesis of 3,2'-Pyrrolinyl Spirooxindoles via Conjugate Addition/Schmidt-type Rearrangement of Vinyl Azides and (E)-Alkenyloxindoles, Chem. Sci. 2020, 11, 11492−11497.

19. Liuzhen Hou, Tengfei Kang, Liangkun Yang, Weidi Cao,* Xiaoming Feng,* Enantioselective Imino-Ene Reaction of N-Sulfonyl Ketimines with Silyl Enol Ethers: Access to Chiral Benzosultams, Org. Lett. 2020, 22, 1390−1395.

20. Yu Zhang, Hao Pan, Wen Liu, Weidi Cao,* Xiaoming Feng,*Asymmetric Catalytic Synthesis of Epoxides via Three-Component Reaction of Diazoacetates, 2‑Oxo-3-ynoates, and Nitrosoarenes, Org. Lett. 2020, 22, 6744−6749.

21. Xiangqiang Li, Mingyi Jiang, Tangyu Zhan, Weidi Cao,* Xiaoming Feng,* Catalytic Asymmetric Three-component Hydroacyloxylation/1,4-Conjugate Addition of Ynamides, Chem Asian J. 2020, 15, 1953−1956.

22. Weidi Cao, Xiaohua Liu, Xiaoming Feng,* Chiral N,Nʹ-dioxide and Their Metal Complexes in Asymmetric Catalysis (in Chinese), Chin. Sci. Bull. 2020, 65, 2941−2951.

23. Bin Shen, Wen Liu, Weidi Cao,* Xiaohua Liu, Xiaoming Feng,* Asymmetric Synthesis of α,β-Epoxy-γ-lactams through Tandem Darzens/Hemiaminalization Reaction, Org. Lett. 2019, 21, 47134716.

24. Yan Wang, Kaixuan Wang, Weidi Cao,* Xiaohua Liu, Xiaoming Feng,* Diastereo- and Enantioselective 1,6-Conjugate Addition of 2‑Azaarylacetamides to para-Quinone Methides, Org. Lett. 2019, 21, 6063−6067.

25. Weidi Cao, Xiaoming Feng, Xiaohua Liu,* Reversal of Enantioselectivity in Chiral Metal Complex-catalyzed Asymmetric Reactions, Org. Biomol. Chem. 2019, 17, 6538−6550.

26. Wen Liu, Weidi Cao,* Haipeng Hu, Lili Lin, Xiaoming Feng,* Dynamic Kinetic Asymmetric Transformations of β-Halo-α-Keto Esters by N,N′-Dioxide/Ni(II)-Catalyzed Carbonyl-Ene Reaction, Chem. Commun. 2018, 54, 89018904. (highlighted by Synfacts)

27. Hang Zhang, Qian Yao, Weidi Cao,* Shulin Ge, Jinxiu Xu, Xiaohua Liu and Xiaoming Feng,* Catalytic Enantioselective Ene-type Reactions of Vinylogous Hydrazone: Construction of α-Methylene-g-butyrolactone Derivatives, Chem. Commun. 2018, 54, 12511–12514.

28. Lifeng Wang, Weidi Cao,* Hongjiang Mei, Linfeng Hu, Xiaoming Feng,* Catalytic Asymmetric Synthesis of Chiral Spiro-Cyclopropyl Oxindoles from 3-Alkenyl-Oxindoles and Sulfoxonium Ylides, Adv. Synth. Catal. 2018, 360, 4089-4093. (VIP)

29. Changqiang He, Weidi Cao,* Jianlin Zhang, Shulin Ge, Xiaoming Feng,* Chirall N,N'-Dioxide/Scandium(III)-Catalyzed Asymmetric Alkylation of N-Unprotected 3-Substituted Oxindoles, Adv. Synth. Catal. 2018, 360, 4301-4305. (highlighted by Synfacts)

30. Weidi Cao, Xiaohua Liu,* Xiaoming Feng, Chiral Organobases: Properties and Applications in Asymmetric Catalysis, Chin. Chem. Lett. 2018, 29, 1201−1208.

31. Weidi Cao, Davin Tan, Richmond Lee,* Choon-Hong Tan,* Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane through a Bisguanidinium Silicate Ion Pair, J. Am. Chem. Soc. 2018, 140, 1952−1955.

32. Weidi Cao, Xiaohua Liu, Jing Guo, Lili Lin, Xiaoming Feng,* Asymmetric Tandem 1,5-Hydride Shift/Ring Closure for the Synthesis of Chiral Spirooxindole Tetrahydroquinolines, Chem. Eur. J. 2015, 21, 16321636.

33. Weidi Cao, Xiaohua Liu, Ruixue Peng, Peng He, Lili Lin, Xiaoming Feng,* Catalytic Asymmetric Cross-Dehydrogenative Coupling: Activation of C–H Bonds by a Cooperative Bimetallic Catalyst System, Chem. Commun. 2013, 49, 34703472.

34. Weidi Cao, Xiaohua Liu, Wentao Wang, Lili Lin, Xiaoming Feng,* Highly Enantioselective Synthesis of Tetrahydroquinolines via Cobalt(II)-Catalyzed Tandem 1,5-Hydride Transfer/Cyclization, Org. Lett. 2011, 13, 600603. (highlighted by Synfacts)

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