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新浦京8883平台
师资力量

高戈     教 授(博导)

研究方向:有机化学

联系方式:028-85418195          Email:gg2b@scu.edu.cn

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简历:

19949 - 19987月,四川大学化学系,本科

19989 - 20047月,四川大学化学系,博士研究生

20053 - 20085月,美国University of Virginia,博士后

20087 - 现在,新浦京8883平台,任教

学术兼职

《中国化学快报》青年编委会委员,2014.10 - 2021.6

《中国化学快报》编委会委员,2021.7 -

主要研究方向

基于芳杂环功能化修饰的有机合成方法学研究

开发基于芳杂环的新型有机功能分子

主要工作业绩

主要围绕芳杂环,开发简洁高效的新反应对其进行合成和修饰,以用于构建新颖的功能型有机分子,设计合成可高效实现有机反应过程转化的新型催化剂。现已发展了高效的咪唑直接芳基季胺化构筑咪唑鎓的方法;发展了咪唑鎓分子的直接C–H芳基化的方法,开发了咪唑鎓电致变色新性能;发展了多个基于碳氢键串联环化的高效构筑离子型天然产物骨架的方法;发展了高活性吡喃鎓中间体的构筑与转化方法,发展了一锅法合成12-氮杂芘鎓盐的方法;首次合成了一种刚性四咪唑鎓大环,可在水中高效识别硫酸根阴离子;提出了铑催化反应中底物作为配体原位配位铑中心的过渡态新策略,成功实现含咪唑鎓单元的阳离子型三亚杂芳烃骨架的高效构筑;提出了构筑近红外Indazo-Fluor小分子荧光探针的D-Het(ED)-Het(ER)-A骨架模型。2013年入选教育部新世纪优秀人才计划。目前已在JACSACIEOLCCJOC等杂志上发表研究论文60余篇。

主要奖励和荣誉

2007第一届中国百篇最具影响优秀国际学术论文

2011教育部自然科学奖一等奖,第6完成人。

2013年,教育部新世纪优秀人才

2018年,四川大学大学生创新创业教育优秀指导教师

2021年,四川大学“大学生创新创业与实践教育优秀指导教师”

学术报告

1. Multiple mechanisms in one-pot cascade C–H fusion reactions 中国化学快报有机化学家论坛,2019,郑州

2. Two-Fold C−H/C−H Cross-Coupling Using RhCl3·3H2O as the Catalyst 第三届华侨大学国际有机合成前沿讨论会,2018,厦门

3. “烯酮的C−H键活化/炔环化反应研究”第八届西部有机论坛,2017,遵义

4. “绿色偶联脱羧反应”第六届西部有机论坛,2015,西安

代表性成果(获奖成果、专著、论文、专利)

1. Zheng, X.; Huang, Z.; Zheng, Q.; Wang, W.; Zhang, C.; Gao, G.* Planar Tetraindolodipleiadiene via Zirconium-Promoted Intramolecular Indolyl C4–H Homocoupling Org. Lett. 2022, 24, 4197.

2. Wang, L.; Zheng, X.; Zheng, Q.; Li, Z.; Wu, J.; Gao, G.* Thioether-Assisted Cu-Catalyzed C5–H Arylation of Imidazo[1,5-a]pyridines Org. Lett. 2022, 24, 3834.

3. Wang, T.; Zheng, X.; Zheng, Q.; Zhou, F.; Wang, L.; Gao, G.* Ni(II)-Catalyzed C–H Hydroarylation of Diarylacetylenes with Imidazolium Salts Chem. Commun. 2022, 58, 2730.

4. Wang, T.; Zheng, Q.; Wang, L.; Huang, Z.; Zhang, H.; Zhang, Y.; Zhang, C.; Gao, G.* Synthesis of Cationic π-Extended Imidazolium Salts by Sequential Cu-Catalyzed Arylation/Annulation and Photocyclization Chem. Commun. 2022, 58, 541.

5. Liu, Y.; She, Z.; Zheng, Q.; Zheng, X.; Wang, T.; Gao, G.* Rigid Chelating Dicarbene Ligands Based on Naphthyridine-Fused Bisimidazolium Salts Chin. Chem. Lett. 2022, 33, 2993.

6. Yu, C.; Zheng, Q.; Wang, L.; Wang, T.; Zheng, X.; Gao, G.* A Prototype of Benzobis(imidazolium)-embedded Conjugated Polyelectrolyte: Synthesis by Direct C‒H Arylation and Fluorescent Responses to Anions Chin. Chem. Lett. 2022, 33, 2425.

7. Wang, C.; Han, S.; Wang, T.; Zheng, X.; Zhou, L.; Liu, Y.; Zhang, C.; Gao, G.* Red Fluorescent Zwitterionic Naphthalenediimide with Di/mono-benzimidazolium and a Negatively Charged Oxygen Substituent Chem. Commun. 2021, 57, 9422.

8. Li, C.; Huang, Z.; Hu, Y.; Liang, W.; Su, R.; Chen, M.; Zhou, L.; Wu, D.; Gao, G.* You, J.* Synthesis of Imidazole-Based [30]Heptaphyrin and Stable Figure-Eight [60]Tetradecaphyrins via [5 + 2] Condensations in One Pot Org. Lett. 2021, 23, 3746.

9. Zhao, T.; Pu, X.; Han, W.; Gao, G.* Nickel-Catalyzed 3,3-Dialkynylation of 2-Aryl Acrylamides: Direct Access to gem-Diethynylethenes via Double Vinylic C–H Bond Activation Org. Lett. 2021, 23, 1199.

10. Wang, D.; Liu, Y.; Wang, L.; Cheng, H.; Zhang, Y.; Gao, G.* Synthesis of π-extended dibenzo[d,k]ullazines by a palladium-catalyzed double annulation using arynes Chin. Chem. Lett. 2021, 32, 1407.

11. Yu, Z.; Zhang, Y.; Tang, J.; Zhang, L.; Liu, Q.; Li, Q.; Gao, G.;* You, J.* Ir-Catalyzed Cascade C−H Fusion of Aldoxime Ethers and Heteroarenes: Scope and Mechanisms ACS Catal. 2020, 10, 203.

12. Wang, Z.; Wang, F.; Liu, Z.; He, S.; Pu, X.; Yang, Y.; Gao, G.* Direct C–H/C–H Cross-Coupling of Benzimidates with Heteroarenes to Access Biheteroaryl-2-carbonitriles Chem. Commun. 2019, 55, 10599.

13. Zhao, T.; Qin, D.; Han, W.; Yang, S.; Feng, B.; Gao, G.;* You, J.* Co(III)-Catalyzed Z-Selective Oxidative C–H/C–H Cross-Coupling of Alkenes with Triisopropylsilylacetylene Chem. Commun. 2019, 55, 6118.

14. Zheng, X.; Su, R.; Wang, Z.; Wang, T.; Bin, Z.; She, Z.; Gao, G.;* You, J. Synthesis of a Double-Helical Naphthotetraindole Core via an Intramolecular Dehydrogenative Homocoupling Reaction Org. Lett. 2019, 21, 797.

15. Kadam, V. D.; Feng, B.; Chen, X.; Liang, W.; Zhou, F.; Liu, Y.; Gao, G.;* You J.* Cascade C‒H Annulation Reaction of Benzaldehydes, Anilines, and Alkynes toward Dibenzo[a,f]quinolizinium Salts: Discovery of Photostable Mitochondrial Trackers at the Nanomolar-Level Org. Lett. 2018, 20, 7071.

16. She, Z.; Wang, Y.; Wang, D.; Zhao, Y.; Wang, T.; Zheng, X.; Yu, Z.-X.;* Gao, G.;* You, J.* Two-Fold C−H/C−H Cross-Coupling Using RhCl3·3H2O as the Catalyst: Direct Fusion of N-(Hetero)arylimidazolium Salts and (Hetero)arenes J. Am. Chem. Soc. 2018, 140, 12566.

17. Zhao, Y.; Zheng, Q.; Yu, C.; Liu, Z.; Wang, D.; You, J.; Gao, G.* Rh(III)-Catalyzed Regioselective C–H [4+2] C-Annulation of Vinyl Enaminones with Alkynes to Form Polysubstituted Salicylaldehydes Org. Chem. Front. 2018, 5, 2875.

18. Zhao, Y.; Yu, C.; Wang, T.; She, Z.; Zheng, X.; You, J. Gao, G.* Tandem Rh-Catalyzed [4 + 2] Vinylic C−H O-Annulation of Exocyclic Enones with Alkynes and 1,5-H Shift Org. Lett. 2018, 20, 1074.

19. Li, S.; Tang, J.; Zhao, Y.; Jiang, R.; Wang, T.; Gao, G.;* You, J.* Cu-Catalyzed Selective C‒H Mono-/Di-/Triarylation of Imidazolium Salts for Ionic Functional Materials Chem. Commun. 2017, 53, 3489.

20. Zhao, Y.; Li, S.; Zheng, X.; Tang, J.; She, Z.; Gao, G.;* You, J.* Rh/Cu-Catalyzed Cascade [4+2] Vinylic C–H O-Annulation and Ring Contraction of a-Aryl Enones with Alkynes in Air Angew. Chem. Int. Ed. 2017, 56, 4286.

21. Tang, J.; Li, S.; Liu, Z.; Zhao, Y.; She, Z.; Kadam, V. D.; Gao, G.;* Lan, J.; You, J.* Cascade C‒H Annulation of Aldoximes with Alkynes using O2 as the Sole Oxidant: One-Pot Access to Multisubstituted Protoberberine Skeletons Org. Lett. 2017, 19, 604.

22. He, Z.; Qi, X.; She, Z.; Zhao, Y. Li, S.; Tang, J.; Gao, G.;* Lan, Y.;* You, J.* Room-Temperature Coupling/Decarboxylation Reaction of α-Oxocarboxylates with α-Bromoketones: Solvent-Controlled Regioselectivity for 1,2- and 1,3-Diketones J. Org. Chem. 2017, 82, 1403.

23. Feng, B.; Wan, D.; Yan, L.; Kadam, V. D.; You, J.; Gao, G.* A Facile Access to Substituted Cationic 12-Azapyrene Salts by Rhodium(III)-Catalyzed C–H Annulation of N-Arylpyridinium Salts RSC Adv. 2016, 6, 66407.

24. Cheng, Y.; Li, G.; Liu, Y.; Shi, Y.; Gao, G.;* Wu, D.; Lan, J.; You, J.* Unparalleled Ease of Access to a Library of Biheteroaryl Fluorophores via Oxidative Cross-Coupling Reactions: Discovery of Photostable NIR Probe for Mitochondria J. Am. Chem. Soc. 2016, 138, 4730.

25. Zhao, Y.; He, Z.; Li, S.; Tang, J.; Gao, G.;* Lan, J.; You, J.* An Air-stable Half-sandwich RuII Complex as Efficient Catalyst for [3+2] Annulation of 2-Arylcyclo-2-enones with Alkynes Chem. Commun. 2016, 52, 4613. (Cover story)

26. Qin, D.; Wang, J.; Qin, X.; Wang, C.; Gao, G.;* You, J.* Rh(III)-catalyzed oxime ether-directed heteroarylation of arene through oxidative C–H/C–H cross-coupling Chem. Commun. 2015, 51, 6190.

27. He, Z.; Qi, X.; Li, S.; Zhao, Y.; Gao, G.;* Lan, Y.;* Wu, Y.; Lan, J.; You, J.* Transition-Metal-Free Formal Decarboxylative Coupling of α-Oxocarboxylates with α-Bromoketones under Neutral Conditions: A Simple Access to 1,3-Diketones Angew. Chem. Int. Ed. 2015, 54, 855.

28. Li, S.; Yang, F.; Lv, T.; Lan, J.; Gao, G.;* You, J.* Synthesis of Unsymmetrical Imidazolium Salts by Direct Quaternization of N-Substituted Imidazoles with Arylboronic Acids Chem. Commun. 2014, 50, 3941.

29. Zhou, H.; Zhao, Y.; Gao, G.;* Li, S.; Lan, J.; You, J.* Highly Selective Fluorescent Recognition of Sulfate in Water by Two Rigid Tetrakisimidazolium Macrocycles with Peripheral Chains J. Am. Chem. Soc. 2013, 135, 14908.

30. Lv, T.; Yang, L.; Zhao, Y.; Song, F.; Lan, J.; You, J.;* Gao, G.* One-pot Synthesis of Diarylimidazolium Salts from 1H-Imidazole Chin. Chem. Lett. 2013, 24, 773.

31. Hu, J.; He, Z.; Wang, Z.; Li, X.; You, J.; Gao, G.* A Simple Approach to Aggregation-Induced Emission in Difluoroboron Dibenzoylmethane Derivatives Tetrahedron Lett. 2013, 54, 4167.

32. Lv, T.; Wang, Z.; You, J.;* Lan, J.; Gao, G.* Copper-Catalyzed Direct Aryl Quaternization of N-Substituted Imidazoles to Form Imidazolium Salts J. Org. Chem. 2013, 78, 5723.

33. Zhou, H.; Wang, Z.; Gao, C.; You, J.; Gao, G.* Synthesis and Characterization of a Luminescent and Fully Rigid Tetrakisimidazolium Macrocycle Chem. Commun. 2013, 49, 1832.

34. Gao, C.; Zhou, H.; Wei, S.; Zhao, Y.; You, J.; Gao, G.* Novel Bisimidazolium Pincers as Low Loading Ligands for in situ Palladium-Catalyzed Suzuki-Miyaura Reaction in the Ambient Atmosphere Chem. Commun. 2013, 49, 1127.

35. Yang, S.; You, J.;* Lan, J.; Gao, G.* Facile Access to Extremely Efficient Energy-Transfer Pairs via an Unexpected Reaction of Squaraines with Ketones J. Am. Chem. Soc. 2012, 134, 11868.

36. Cheng, L.; Dong, J.; You, J.; Gao, G.;* Lan, J.* A Highly syn-Selective Nitroaldol Reaction Catalyzed by CuII-Bisimidazoline Chem. -Eur. J. 2010, 16(23), 6761.

37. Gao, G.;* Pu, L.* γ-Hydroxy-α,β-acetylenic esters: asymmetric syntheses and applications Sci China Chem. 2010, 53, 21.

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