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新浦京8883平台
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张 骥     教 授,化学生物学教研室主任

研究方向:化学生物学,有机化学

联系方式:028-85418580          Email:jzhang@scu.edu.cn

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个人简介

教授,博士生导师。2002年于新浦京8883平台获理学博士学位,师从谢如刚教授。之后历任香港大学Research Assistant、新浦京8883平台讲师、副教授、教授。2011年入选教育部“新世纪优秀人才支持计划”,第十三批四川省学术和技术带头人后备人选,中国化学会高级会员。从事有机化学、化学生物学教学科研工作,国家级一流本科课程《有机化学(I)》负责人,四川大学“探究式-小班化”教学示范教师及示范课程负责人,主编本科教材1部。科研方向为纳米生物材料,获多项国家自然科学基金、重点研发项目子课题、省应用基础项目等资助,以第一/通讯作者发表SCI论文80余篇,主编英文专著1部。

教学科研概况

讲授本科课程:

《有机化学(I)》(203112030 & 203113030, 国家级一流本科课程)

《生物化学》(203080030, 双语课程)

《化学生物学实验》(203197020

《有机化学实验》

《应用化学设计实验》(203130020

讲授研究生课程:

《生物材料化学》(M0703Z202

科研方向:

纳米生物材料:新型核酸和药物递送系统的设计和构建,基因/药物载体的构效关系,以及相关基因治疗和免疫治疗研究。

主要工作业绩

教育部“新世纪优秀人才支持计划”(2011);

国家级一流线下本科课程《有机化学(I)》负责人(2023);

四川省学术和技术带头人后备人选(第十三批,2021);

教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖(2010,排名第三);

四川大学第七届“姜维平优秀教学奖”(2021);

四川大学第四届“探究式-小班化”教学竞赛一等奖、四川大学“探究式-小班化”教学示范教师/课程(有机化学I)(2021);

四川大学首届“五粮春青年教师优秀教学奖”(2015);

四川大学先进个人(优秀教师)(2015~16);

四川大学十佳青年教师教学奖(2012~13);

及其它各类校级教学奖励20余项。

代表性成果 (获奖成果、专著、论文、专利)

获奖成果:

简单金属盐催化的C-C键和C-N键形成反应,教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖,2010,第三完成人。

主编著作:

1. 《有机化学基础》(第三版),2020,科学出版社。ISBN: 978-7-03-064996-6.

2. , 2018, Wiley-VCH, ISBN: 978-3-527-34187-0.

近年部分代表性论文:

1. Chen, P.; He, X.; Hu, Y.; Tian, X.-L.; Yu, X.-Q.; Zhang, J. “Spleen-targeted mRNA delivery based on polyamine carbon dots for tumor immunotherapy” ACS Appl. Mater. Interf. 2023, 15(16), 19937-19950.

2. Yang, H.-Z.; Guo, Y.; Pu, L.; Yu, X.-Q.; Zhang, J. “Fluorescent self-reporting lipid nanoparticles for NO / gene co-delivery and combination therapy” Mol. Pharm. 2023, 20(2), 1404-1414.

3. Zhan, Y.-R.; Chen, P.; He, X.; Hei, M.-W.; Zhang, J.; Yu, X.-Q. “Sodium alginate-doping cationic nanoparticle as dual gene delivery system for genetically bimodal therapy” Biomacromolecules 2022, 23(12), 5312-5321.

4. Guo, Y.; He, X.; Zhao, R.-M.; Yang, H.-Z.; Huang, Z.; Zhang, J.; Yu, X.-Q. “Zn-dipicolylamine-based reactive oxygen species-responsive lipids for siRNA delivery and in vivo colitis treatment” Acta Biomater. 2022, 147, 287-298.

5. Zhan, Y.-R.; Tan, J.; Hei, M.-W.; Zhang, S.-Y.; Zhang, J.; Yu, X.-Q. “Construction of GSH-triggered cationic fluoropolymer as two-in-one nanoplatform for combined chemo/gene therapy” J. Mater. Chem. B 2022, 10(8), 1308-1318.

6. Chen, P.; He, X.; Zhang, J.; Tian, X.-L.; Yu, X.-Q. “One-Step Fabrication of Functional Carbon Dots with Long Wavelength Emission for Gene Delivery and Bio-imaging” J. Mater. Chem. B 2021, 9(40), 8518-8529.

7. Chen, P.; Zhang, J.; He, X.; Liu, Y.-H.; Yu, X.-Q. “Hydrophobically Modified Carbon Dots as Multifunctional Platform for Serum-Resistant Gene Delivery and Cell Imaging” Biomater. Sci. 2020, 8(13), 3730-3740.

8. Xiao, Y.-P.; Zhang, J.; Liu, Y.-H.; Huang, Z.; Guo, Y.; Yu, X.-Q. “Bioinspired pyrimidine-contained cationic polymers as effective nano-carriers for DNA and protein delivery” J. Mater. Chem. B 2020, 8(11), 2275-2285.

9. He, X.; Luo, Q.; Zhang, J.; Chen, P.; Wang, H.-J.; Luo, K.; Yu, X.-Q. “Gadolinium-doped Carbon Dots as Nano-theranostic Agent for MR/FL Imaging and Gene Delivery” Nanoscale 2019, 11(27), 12973-12982.

10. He, X.; Chen, P.; Zhang, J.; Luo, T.-Y.; Wang, H.-J.; Liu, Y.-H.; Yu, X.-Q. “Cationic Polymer-Derived Carbon Dots for Enhanced Gene Delivery and Cell Imaging” Biomater. Sci. 2019, 7(5), 1940-1948.

11. Yu, Q.-Y.; Guo, Y.; Zhang, J.; Huang, Z.; Yu, X.-Q. “Zn(II) coordination to cyclen-based polycations for enhanced gene delivery” J. Mater. Chem. B 2019, 7(3), 451-459.

12. Zhang, Y.-M; Huang, Z.; Wu, X.-R.; Zhang, J.; Liu, Y.-H.; Yu, X.-Q. “A small combinatorial library of lipidoids as gene delivery vectors” ACS Appl. Nano Mater. 2018, 1(8), 3925-3934.

13. Wang, B.; Zhang, J.; Liu, Y.-H.; Zhang, W.; Xiao, Y.-P.; Zhao, R.-M.; Yu, X.-Q. “A reduction-responsive liposomal nanocarrier with self-reporting ability for efficient gene delivery” J. Mater. Chem. B 2018, 6(18), 2860-2868.

14. Xiao, Y.-P., Zhang, J.; Liu, Y.-H.; Chen, X.-C.; Yu, Q.-Y.; Luan, C.-R.; Zhang, J.-H.; Wei, X.; Yu, X.-Q. “Ring-opening polymerization of diepoxides as an alternative method to overcome PEG dilemma in gene delivery” Polymer 2018, 134, 53-62.

15. Wang, B.; Chen, P.; Zhang, J.; Liu, Y.-H.; Huang, Z.; Yu, Q.-Y.; Zhang, J.-H.; Zhang, W.; Yu, X.-Q. “Self-assembled core-shell-corona multifunctional AIE non-viral vector for efficient hepatocytes targeting gene delivery” Polymer Chem. 2017, 8(48), 7486-7498.

16. Xiao, Y.-P.; Zhang, J.; Liu, Y.-H.; Huang, Z.; Wang, B.; Zhang, Y.-M.; Yu, X.-Q. “Cross-linked polymers with fluorinated bridge for efficient gene delivery” J. Mater. Chem. B 2017, 5(43), 8542-8553.

17. Wang, H.-J.; He, X.; Luo, T.-Y.; Zhang, J.; Liu, Y.-H.; Yu, X.-Q. “Amphiphilic carbon dots as versatile vector for nucleic acid and drug delivery” Nanoscale. 2017, 9(18), 5935-5947.

18. Zhang, Y.-M; Huang, Z.; Zhang, J.; Wu, W.-X.; Liu, Y.-H.; Yu, X.-Q. “Amphiphilic polymers from ring-opening polymerization: a strategy for the enhancement of gene delivery” Biomater. Sci. 2017, 5(4), 718-729.

19. Huang, Z.; Zhang, Y.-M.; Cheng, Q.; Zhang, J.; Liu, Y.-H.; Wang, B.; Yu, X.-Q. “Structure-activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors” J. Mater. Chem. B 2016, 4(33), 5575-5584.

20. Luan, C.-R.; Liu, Y.-H.; Zhang, J.; Yu, Q.-Y.; Huang, Z.; Wang, B.; Yu, X.-Q. “Low molecular weight oligomers with aromatic backbone as efficient non-viral gene vectors” ACS Appl. Mater. Interf. 2016, 8(17), 10743-10751.

21. Xun, M.-M.; Xiao, Y.-P.; Zhang, J.; Liu, Y.-H.; Peng, Q.; Guo, Q.; Wu, W.-X.; Xu, Y.; Yu, X.-Q. “Low molecular weight PEI-based polycationic gene vectors via Michael addition polymerization with improved serum-tolerance” Polymer 2015, 65, 45-54.

22. Guo, Q.; Liu, Y.-H.; Xun, M.-M.; Zhang, J.; Huang, Z.; Zhou, X.-D.; Yu, X.-Q. “Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles” J. Mater. Chem. B 2015, 3(13), 2660-2670.

23. Zhang, Q.-F.; Yu, Q.-Y.; Geng, Y.; Zhang, J.; Wu, W.-X.; Wang, G.; Gu, Z.; Yu, X.-Q. “Ring-opening polymerization for hyperbranched polycationic gene delivery vectors with excellent serum tolerance” ACS Appl. Mater. Interfaces 2014, 6(18), 15733-15742.

24. Yi, W.-J.; Yu, X.-C.; Wang, B.; Zhang, J.; Yu, Q.-Y.; Zhou, X.-D.; Yu, X.-Q. “TACN-based oilgomers with aromatic backbones for efficient nucleic acid delivery” Chem. Commun. 2014, 50(49), 6454-6457.

25. Yi, W.-J.; Zhang, Q.-F.; Zhang, J.; Liu, Q.; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q. “Cyclen-based lipidic oligomers as potential gene delivery vehicles” Acta Biomater. 2014, 10(3), 1412-1422.

26. Wang, H.-J.; Liu, Y.-H.; Zhang, J.; Zhang, Y.; Xia, Y.; Yu, X.-Q. “Cyclen-based cationic lipids with double hydrophobic tails for efficient gene delivery” Biomaterials Sci. 2014, 2(10), 1460-1470.

27. Zhang, Q.-F.; Yi, W.-J.; Wang, B.; Zhang, J.; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q. “Linear polycations by ring-opening polymerization as non-viral gene delivery vectors: structure-activity relationship studies” Biomaterials 2013, 34(21), 5391-5401.

 

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